Generic placeholder image

Letters in Organic Chemistry

Author(s): Mohammad Majid Mojtahedi, Nina Niknejad and Hojat Veisi

DOI: 10.2174/1570178611310020010

DownloadDownload PDF Flyer Cite As
A Mild and Green Method for the N-BOC Protection of Amines without Assistant of Catalyst Under Solvent-free Conditions

Page: [121 - 125] Pages: 5

  • * (Excluding Mailing and Handling)

Explore Articles
About Journal
For Authors
For Editors
For Reviewers

Abstract

A facile, green and versatile method for the Boc protection of amines has been developed by a treatment with (Boc)2O without any additive at room temperature. The method is general for the preparation of N-Boc derivatives of aliphatic (acyclic and cyclic), aromatic, and heteroaromatic amines; primary and secondary amines. The advantages of this method are green, simplicity, short reaction times and excellent yields.

Keywords: N-BOC protection, green, catalyst-free, solvent-free