Abstract

Tandem or sequential processes involving the Wittig reaction have been extensively used over the past decade in light of their potential in organic synthesis for the construction of complex molecules from simple precursor in a single process. This review is centered on the use of one-pot processes involving Wittig as the core reaction for the synthesis of highly functionalized and biologically important compounds and also for the total synthesis of natural products. The major exploits in this area of research for last decade are highlighted which demonstrate the enormous power of these processes in organic synthesis and underscores the ingenuity of synthetic chemists to achieve higher level of elegance and efficiency.

Keywords: One-pot, phosphorane, sequential, tandem, wittig, ylide