Abstract

The advances in the chemistry of Mannich bases of electron-rich, monocyclic five-membered heterocycles with one heteroatom thiophene and furan are reviewed. The aminomethylation of these heterocycles along with the reactivity and the applications of their Mannich bases are summarized.

Keywords: Aminomethylation, mannich reaction, mannich bases, thiophene, furan, drug design