Author(s): Mukesh P. Shewalkar, Ramakrishna R. Rao, Veerbhadra Reddy, Sunil N. Darandale and Devanand B. Shinde
Page: [60 - 64] Pages: 5
* (Excluding Mailing and Handling)
A convenient method for the synthesis of organic carbamates of 2-aminopyridine without using hazardous chloroformate reagent is developed. This alternate approach for the synthesis of organic carbamates and their alkylation to 2-alkylaminopyridines is more practical and economical to be used on large scale. The amazing behavior of 2- aminopyridine helps in forming organic carbamates unlike 3-aminopyridine and 4-aminopyridine.
Keywords: Alkylation, alkyl aminopyridine, 2-aminopyridine, Boc anhydride, carbamates, prodrugs, maytansine, alkylation, toxic, economical method, chemicals
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