Abstract

A general synthetic route to synthesis of N-cyclohexyl-3-aryl-quinoxaline-2-amines has been developed using ZnO nanoparticles under mild conditions. The multi-component reactions of aldehydes, o-phenylenediamine and cyclohexyl isocyanide were carried out to afford some N-cyclohexyl-3-aryl-quinoxaline-2-amines derivatives. The present approach offers several advantages such as high yields, environmentally benign, easy purification, recovery and reusability of the catalyst.

Keywords: N-cyclohexyl-3-aryl-quinoxaline-2-amines, ZnO nanoparticles, heterogeneous catalyst, multi-component, isocyanides, reagent, toluene, diffraction peak, purity, SEM image