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Letters in Organic Chemistry

Author(s): Palle Sadanandam, Nomula Sathaiah, Vantikommu Jyothi, Murugulla A. Chari, Donthabakthuni Shobha, Parthasarathi Das and Khagga Mukkanti

DOI: 10.2174/157017812803521126

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Synthesis and Characterisation of 5-(6-substituted phenyl -2H-chromen-3- yl) Oxazole Derivatives

Page: [683 - 690] Pages: 8

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Abstract

Here we demonstrate the synthesis of various derivatives of 5-(6-substituted phenyl-2H-chromen-3-yl)- oxazoles 5(a-k) by using Suzuki coupling conditions with different substituted boronic acids and obtained 23-57 % yields. We also synthesised various derivatives of the 5-(substituted 2H-chromen-3-yl)-oxazoles 3(a-j) mediated by TOSMIC as a reagent and achieved 58-70 % yield.

Keywords: 5-(substituted 2H-chromen-3-yl)-oxazoles, 5-(6-substituted phenyl-2H-chromen-3-yl)-oxazoles, suzuki coupling, TOSMIC reagent, pharmaceutically significant, natural products, derivatives, human rhinovirus 3c protease, conjugate addition, antidiabetic activity