Abstract

A series of novel pyrimido[4,5-b]quinoline-4,6(3H,5H,7H,10H)-dione derivatives was synthesized by one-pot three-component reaction of the appropriate aldehyde, dimedone or cyclohexanedione and 6-aminothiouracil in ethanol under ultrasonic irradiation at 50 oC in short reaction times (1.5-3 min) and excellent yields (94-99%). The antibacterial activities of the synthesized compounds were evaluated on M. leuteus, B. subtilis, E. coli and Ps. aeruginosa. All the synthesized products showed good antibacterial activities.

Keywords: 6-aminothiouracil, antibacterial, MCR, one-pot, pyrimido[4, 5-b]quinolone, pyridopyrimidine, pyrazole, ultrasound, synthesis, yields