Author(s): N. A.A. Balatsos, P. Maragozidis, D. Anastasakis and C. Stathopoulos
Page: [4838 - 4849] Pages: 12
* (Excluding Mailing and Handling)
Deadenylation is the exoribonucleolytic shortening of eukaryotic poly(A) tails. It is often the first and rate-limiting step for mRNA decay and translational silencing. The process is catalysed by a diversity of deadenylases, which provide robust and flexible means to control mRNA levels and gene expression. Poly(A)-specific ribonuclease (PARN) is a major mammalian deadenylase and the only known to concurrently bind the 5' cap-structure and the 3' poly(A), thus enhancing the degradation rate and amplifying its processivity. PARN is important during oocyte maturation, embryogenesis, early development, DNA damage, and in cell-cycle progression, but also in processes beyond mRNA metabolism, such as the maturation of snoRNAs. The enzyme also participates in nonsense-mediated mRNA decay and in the regulation of cytoplasmic polyadenylation. Importantly, PARN is involved in the degradation of several cancerrelated genes, while its expression is altered in cancer. Apart from the direct interaction with the cap structure, several strategies regulate PARN activity, such as phosphorylation, interaction with RNA-binding proteins (RBPs), and natural nucleotides. Recent studies have focused on the regulation of its activity by synthetic nucleoside analogues with therapeutic potential. In this context, the wide repertoire of RBPs and molecules that regulate PARN activity, together with the established role of deadenylases in miRNA-mediated regulation of mRNA expression, suggest that mRNA turnover is more complex than it was previously thought and PARN holds a key role in this process. In this review, we highlight the importance of PARN during RNA’s lifecycle and discuss clinical perspectives of modulating its activity.
Keywords: PARN, deadenylation, mRNA turnover, inhibitors, cancer
1 x Application (66.86%) | 208ms |
1 x Booting (33.13%) | 103ms |
Backtrace |
|
INSERT INTO visitor_ip_address (ip_address,visitor_agent,visitor_count, created_on,updated_on) VALUES ('51415869','',1,1736989528,1736989528)
ON DUPLICATE KEY UPDATE visitor_count=visitor_count + 1, updated_on=1736989528
Backtrace |
|
INSERT INTO visitor_ip_address_detail (ip_address,visitor_url,visitor_count, created_on,updated_on) VALUES ('51415869','/article/46234',1,1736989528,1736989528)
Backtrace |
|
(select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_journal_volume_trail WHERE to_ip >= 51415869 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 51415869) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_journal_volume_corporate WHERE to_ip >= 51415869 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 51415869) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_journal_volume_token WHERE to_ip >= 51415869 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 51415869) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_ebook_volume_trail WHERE to_ip >= 51415869 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 51415869) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_ebook_volume_corporate WHERE to_ip >= 51415869 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 51415869) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_ebook_volume_token WHERE to_ip >= 51415869 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 51415869) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_issue_trail WHERE to_ip >= 51415869 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 51415869) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_issue_corporate WHERE to_ip >= 51415869 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 51415869) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_issue_token WHERE to_ip >= 51415869 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 51415869) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_article_trail WHERE to_ip >= 51415869 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 51415869) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_article_corporate WHERE to_ip >= 51415869 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 51415869) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_article_token WHERE to_ip >= 51415869 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 51415869) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_chapter_trail WHERE to_ip >= 51415869 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 51415869) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_chapter_corporate WHERE to_ip >= 51415869 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 51415869) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_chapter_token WHERE to_ip >= 51415869 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 51415869) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_disease_corporate WHERE to_ip >= 51415869 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 51415869) limit 1
Bindings |
|
Backtrace |
|
SELECT at.type_name, p.copyright, p.publisher_location,m.month,y.year,
a.publish_on, a.nid article_nid,a.article_id, a.pmid, a.issue_id, a.title, a.abstract,a.podcast,a.altmetric_score,a.altmetric_url,a.kudos_url, a.page_count, a.first_page, a.elocator,
a.last_page, i.publication_date, a.file_name,
a.file_path, a.doi, a.is_epub,a.epub_type, a.volume_id, a.is_uploaded, a.editor_choice, a.is_epub, j.image_file_name,
a.article_no, a.art_type AS article_type, a.supplementary_filename,a.html_filename,a.prc_filename,a.epub_filename, a.graph_abs_lg_filename, a.graph_abs_sm_filename, a.oa_image_lg_filename, a.oa_image_sm_filename, j.journal_banner,a.animated_abstract,a.erratum_in,a.erratum_for,
(CASE WHEN a.issue_id =0 THEN j.epub_price ELSE j.price END) AS sell_price, j.epub_price, j.nid AS jour_nid, j.title AS journal_title, j.issn, j.eissn,j.journal_id, j.subtitle AS jour_subtitle,
v.volume_id,v.volume_name AS volume, v.year_id, i.title AS issue, i.month_id ,i.type issue_type, j.subtitle,j.formerly_title, ac.subtitle AS epub_title,a.crossmark_enabled,a.text_mining_urls,a.license_urls,a.created, a.receivedate, a.revisedate, a.acceptdate,js.js_title
FROM article a
LEFT JOIN article_section ac ON a.is_epub = ac.art_sec_id
LEFT JOIN journal_section js ON a.js_id = js.js_id
LEFT JOIN article_type at ON a.art_type = at.art_type_id
LEFT JOIN issue i ON a.issue_id = i.issue_id
LEFT JOIN month m ON m.id = i.month_id
LEFT JOIN volume v ON v.volume_id = a.volume_id
INNER JOIN year y ON y.id = v.year_id
INNER JOIN journal j ON j.journal_id = a.journal_id
INNER JOIN publisher p ON p.publisher_id = j.publisher_id
WHERE a.article_id=46234
Backtrace |
|
select * from `journal` where `journal_id` = 25 limit 1
Bindings |
|
Backtrace |
|
select count(*) as aggregate from (select j.nid as journal_nid,j.flyer_link,j.title ,j.issn,j.eissn,j.keyword,
j.journal_id as journal_id, j.subtitle, j.image_file_name,j.description,j.journal_insight_url,j.doi from `subject_journal` as `sj` inner join `journal` as `j` on `j`.`journal_id` = `sj`.`journal_id` where j.journal_status=1 and subject_id IN (SELECT subject_id FROM subject_journal WHERE journal_id=25) and sj.journal_id!=25 group by `j`.`nid`) as `aggregate_table`
Backtrace |
|
select j.nid as journal_nid,j.flyer_link,j.title ,j.issn,j.eissn,j.keyword,
j.journal_id as journal_id, j.subtitle, j.image_file_name,j.description,j.journal_insight_url,j.doi from `subject_journal` as `sj` inner join `journal` as `j` on `j`.`journal_id` = `sj`.`journal_id` where j.journal_status=1 and subject_id IN (SELECT subject_id FROM subject_journal WHERE journal_id=25) and sj.journal_id!=25 group by `j`.`nid` order by `j`.`journal_id` asc limit 10 offset 0
Backtrace |
|
select count(*) as aggregate from (select v.nid as volume_id,e.nid,e.title,v.issn,v.eissn,v.isbn,v.eisbn,e.ebook_id,
v.image_file_name,v.file_path,v.flyer_link,v.ebook_volume_id, v.volume_name,v.doi,v.year_id,v.introduction from `subject_ebook` as `se` inner join `ebook` as `e` on `e`.`ebook_id` = `se`.`ebook_id` inner join `ebook_volume` as `v` on `v`.`ebook_id` = `se`.`ebook_id` inner join `year` as `y` on `y`.`id` = `v`.`year_id` where subject_id IN (SELECT subject_id
FROM subject_journal
WHERE journal_id=25) and v.ebook_status='1' and y.year > 2020 group by `v`.`nid`) as `aggregate_table`
Backtrace |
|
select v.nid as volume_id,e.nid,e.title,v.issn,v.eissn,v.isbn,v.eisbn,e.ebook_id,
v.image_file_name,v.file_path,v.flyer_link,v.ebook_volume_id, v.volume_name,v.doi,v.year_id,v.introduction from `subject_ebook` as `se` inner join `ebook` as `e` on `e`.`ebook_id` = `se`.`ebook_id` inner join `ebook_volume` as `v` on `v`.`ebook_id` = `se`.`ebook_id` inner join `year` as `y` on `y`.`id` = `v`.`year_id` where subject_id IN (SELECT subject_id
FROM subject_journal
WHERE journal_id=25) and v.ebook_status='1' and y.year > 2020 group by `v`.`nid` order by `v`.`ebook_volume_id` desc limit 10 offset 0
Backtrace |
|
select * from `keywords` where `article_id` = '46234'
Bindings |
|
Backtrace |
|
select * from `article_citation` where `article_id` = '46234'
Bindings |
|
Backtrace |
|
select CONCAT_WS(' ',au.first_name, ' ', ifnull(au.initials,''), ' ', au.last_name) as authors,
CONCAT(au.last_name, IFNULL(CONCAT(' ', au.initials), ''), ' ', au.first_name) AS authorsRIS, CONCAT_WS(' ',au.last_name, ' ', ifnull(au.initials,''), ' ', au.first_name) as authorsCiteAs , `au`.*, (GROUP_CONCAT(TRIM(BOTH ', ' FROM
CONCAT(ifnull(concat(af.institution,','),''), ifnull(concat(af.department,','),''), ifnull(concat(af.address,','),''), ifnull(concat(af.city,','),''), ifnull(concat(af.country,','),''), ifnull(concat(af.postal_code,','),''), ifnull(concat(af.phone,','),''), ifnull(concat(af.fax,','),'')))
SEPARATOR '|')) as `author_affiliation`, (GROUP_CONCAT(TRIM(BOTH ', ' FROM
CONCAT(ifnull(concat(af.web_view,','),'')))
SEPARATOR '|')) as `web_view` from `author` as `au` left join `author_affiliation` as `af` on `au`.`author_id` = `af`.`author_id` where `au`.`article_id` = '46234' group by `au`.`author_id` order by `au`.`article_id` asc, `au`.`sequence` asc
Bindings |
|
Backtrace |
|
select `bo`.* from `bundle_offer` as `bo` where `bo`.`bundle_status` = 'A' order by `bo`.`bundle_id` desc
Bindings |
|
Backtrace |
|
select `subtitle` from `journal` where `continues_publication_journal` = 1
Bindings |
|
Backtrace |
|
Select j.subtitle, v.volume_id as volume_id,v.year_id,y.year as year,v.volume_name, v.total_no_of_issues, i.issue_id as issue_id,i.title as issue, i.publication_date as issue_pub_date from journal j
join volume v on j.journal_id = v.journal_id
join issue i on v.volume_id = i.volume_id
join article a on a.issue_id = i.issue_id
join year y on v.year_id = y.id
where j.journal_id = 25 and i.is_uploaded = 1
order by v.volume_name+0 desc, i.title+0 desc limit 1
Backtrace |
|
select a.nid,a.publish_on, a.pmid,a.article_id,a.doi,j.journal_id,j.subtitle,v.volume_name,a.volume_id as volume_id,
a.issue_id,a.title,first_page, last_page,
page_count,abstract,ifnull(is_abstract,"y"),asec.title as article_section,at.type_name as article_type_name,
a.article_id as ArticleID ,is_epub,epub_price,epub_type,a.created, y.year from `article` as `a` left join `article_section` as `asec` on `asec`.`art_sec_id` = `a`.`is_epub` left join `article_type` as `at` on `at`.`art_type_id` = `a`.`art_type` left join `journal` as `j` on `j`.`journal_id` = `a`.`journal_id` inner join `volume` as `v` on `a`.`volume_id` = `v`.`volume_id` inner join `year` as `y` on `v`.`year_id` = `y`.`id` where a.article_status != "W" and a.is_epub = 1 and a.journal_id = 25 and a.is_uploaded = 1 group by `a`.`article_id` order by `a`.`last_modified` desc
Backtrace |
|
select a.nid,a.publish_on, a.pmid,a.article_id,a.doi,j.journal_id,j.subtitle,v.volume_name,a.volume_id as volume_id,
a.issue_id,a.title,first_page, last_page,
page_count,abstract,ifnull(is_abstract,"y"),asec.title as article_section,at.type_name as article_type_name,
a.article_id as ArticleID ,is_epub,epub_price,epub_type,a.created, y.year from `article` as `a` left join `article_section` as `asec` on `asec`.`art_sec_id` = `a`.`is_epub` left join `article_type` as `at` on `at`.`art_type_id` = `a`.`art_type` left join `journal` as `j` on `j`.`journal_id` = `a`.`journal_id` inner join `volume` as `v` on `a`.`volume_id` = `v`.`volume_id` inner join `year` as `y` on `v`.`year_id` = `y`.`id` where a.article_status != "W" and a.is_epub = 4 and a.journal_id = 25 and a.is_uploaded = 1 group by `a`.`article_id` order by `a`.`last_modified` desc
Backtrace |
|
select pdf, html, epub, prc from `article_metrics` where `article_id` = 46234 limit 1
Bindings |
|
Backtrace |
|
select * from content_by_diseases
where content_id = 46234 and content_type = 'article' order by status desc limit 1
Backtrace |
|
select a.nid article_nid,a.title article_title,j.title journal_title from content_by_diseases cd
inner join article a on a.article_id=cd.content_id
inner join journal j on j.journal_id=a.journal_id
where cd.pid = 16 and cd.sub_disease_id = 454 and content_id!=46234 and cd.content_type = 'article' order by rand()
limit 20
Backtrace |
|
select * from `node_meta` where `nid` = 103474 limit 1
Bindings |
|
Backtrace |
|
select `bo`.* from `bundle_offer` as `bo` where `bo`.`bundle_status` = 'A' order by `bo`.`bundle_id` desc
Bindings |
|
Backtrace |
|
select * from `tbl_ht_submission` as `h` where `h`.`subtitle` = 'CMC' and (h.proposal_closing_date = 0 OR TO_DAYS(FROM_UNIXTIME(h.proposal_closing_date)) >= TO_DAYS(NOW())) order by `h`.`manuscript` asc
Bindings |
|
Backtrace |
|
select count(*) as total_count, content_type_access_id as access_type from journal_access
where content_type_id = '46234' and content_type = 'a'
and
(
(from_date <= CURDATE() and to_date >= CURDATE() and perpetual= 0) or
(from_date is null and to_date is null and perpetual= 1)
)
Backtrace |
|
select count(*) as total_count, content_type_access_id as access_type from journal_access
where content_type_id = '4747' and content_type = 'i'
and
(
(from_date <= CURDATE() and to_date >= CURDATE() and perpetual= 0) or
(from_date is null and to_date is null and perpetual= 1)
)
Backtrace |
|
select count(*) as total_count, content_type_access_id as access_type from journal_access
where content_type_id = '221' and content_type = 'v'
and
(
(from_date <= CURDATE() and to_date >= CURDATE() and perpetual= 0) or
(from_date is null and to_date is null and perpetual= 1)
)
Backtrace |
|
(select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Trial Access" as access_base_text,
CASE j.type WHEN 111 THEN true ELSE false END as terms_popup,
"S" as content_download_type,
null as restricted_user_access_key,
null as restricted_user_access_type,
CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"volume" as access_level,"" as issue_id,"" as article_id from `user_access_journal_volume_trail` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 51415869 and j.to_ip >=51415869 )) and ((j.from_date <= 1736989528 and j.to_date >= 1736989528 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.volume_id = 221) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Subscribed" as access_base_text,
false as terms_popup,
"S" as content_download_type,
null as restricted_user_access_key,
null as restricted_user_access_type,
CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"volume" as access_level,"" as issue_id,"" as article_id from `user_access_journal_volume_corporate` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 51415869 and j.to_ip >=51415869 )) and ((j.from_date <= 1736989528 and j.to_date >= 1736989528 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.volume_id = 221) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Token Based Access" as access_base_text,
false as terms_popup,
"R" as content_download_type,
j.uc_id as restricted_user_access_key,
"v" as restricted_user_access_type,
CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"volume" as access_level,"" as issue_id,"" as article_id from `user_access_journal_volume_token` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 51415869 and j.to_ip >=51415869 )) and ((j.from_date <= 1736989528 and j.to_date >= 1736989528 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.volume_id = 221)
Backtrace |
|
(select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Trial Access" as access_base_text,
CASE j.type WHEN 111 THEN true ELSE false END as terms_popup,
"S" as content_download_type,
null as restricted_user_access_key,
null as restricted_user_access_type,
CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"issue" as access_level,j.issue_id,"" as article_id from `user_access_issue_trail` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 51415869 and j.to_ip >=51415869 )) and ((j.from_date <= 1736989528 and j.to_date >= 1736989528 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.issue_id = 4747) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Subscribed" as access_base_text,
false as terms_popup,
"S" as content_download_type,
null as restricted_user_access_key,
null as restricted_user_access_type,
CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"issue" as access_level,j.issue_id,"" as article_id from `user_access_issue_corporate` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 51415869 and j.to_ip >=51415869 )) and ((j.from_date <= 1736989528 and j.to_date >= 1736989528 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.issue_id = 4747) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Token Based Access" as access_base_text,
false as terms_popup,
"R" as content_download_type,
j.uc_id as restricted_user_access_key,
"v" as restricted_user_access_type,
CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"issue" as access_level,j.issue_id,"" as article_id from `user_access_issue_token` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 51415869 and j.to_ip >=51415869 )) and ((j.from_date <= 1736989528 and j.to_date >= 1736989528 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.issue_id = 4747)
Backtrace |
|
(select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Trial Access" as access_base_text,
CASE j.type WHEN 111 THEN true ELSE false END as terms_popup,
"S" as content_download_type,
null as restricted_user_access_key,
null as restricted_user_access_type,
CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"article" as access_level, j.issue_id, j.article_id from `user_access_article_trail` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 51415869 and j.to_ip >=51415869 )) and ((j.from_date <= 1736989528 and j.to_date >= 1736989528 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.article_id = 46234) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Subscribed" as access_base_text,
false as terms_popup,
"S" as content_download_type,
null as restricted_user_access_key,
null as restricted_user_access_type,
CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"article" as access_level, j.issue_id, j.article_id from `user_access_article_corporate` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 51415869 and j.to_ip >=51415869 )) and ((j.from_date <= 1736989528 and j.to_date >= 1736989528 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.article_id = 46234) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Token Based Access" as access_base_text,
false as terms_popup,
"R" as content_download_type,
j.uc_id as restricted_user_access_key,
"v" as restricted_user_access_type,
CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"article" as access_level, j.issue_id, j.article_id from `user_access_article_token` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 51415869 and j.to_ip >=51415869 )) and ((j.from_date <= 1736989528 and j.to_date >= 1736989528 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.article_id = 46234)
Backtrace |
|
select * from `article` where `first_page` < '4838' and is_uploaded = 1 and issue_id = 4747 order by cast(first_page as SIGNED) desc limit 1
Bindings |
|
Backtrace |
|
select * from `article` where `last_page` > '4849' and is_uploaded = 1 and issue_id = 4747 order by cast(first_page as SIGNED) asc limit 1
Bindings |
|
Backtrace |
|
select `language_id` from `multilanguage` where `short_code` = 'en'
Bindings |
|
Backtrace |
|
select `source_lang_label`, `target_lang_label` from `multilanguage_labels` where `target_lang_id` = 1
Bindings |
|
Backtrace |
|
select `id` from `multilanguage_article` where `article_id` = 46234 limit 1
Bindings |
|
Backtrace |
|
select b.banner_link, b.banner_name, b.banner_script, b.banner_remarks, b.banner_file_name, b.banner_placement, bd.content_type, bd.content_id from `tbl_banner` as `b` inner join `tbl_banner_detail` as `bd` on `bd`.`banner_id` = `b`.`banner_id` inner join `users` as `u` on `u`.`id` = `b`.`updated_by` inner join `journal` as `j` on `j`.`journal_id` = `bd`.`content_id` where `b`.`banner_journal` = 1 and `bd`.`content_type` = 'J' and `bd`.`content_id` = 25 and `b`.`banner_from_date` <= 1736989528 and `b`.`banner_to_date` >= 1736989528 and `b`.`banner_status` = 'A' order by `b`.`banner_id` desc
Bindings |
|
Backtrace |
|
select count(*) as aggregate from `uc_cart_products` where cart_id='9219fa122ff5945da18148fa6b2ac3b5'
Backtrace |
|
200
[]
[]
0 of 0array:16 [▼ "x-https" => array:1 [▶ 0 => "1" ] "host" => array:1 [▶ 0 => "beta.benthamscience.com" ] "priority" => array:1 [▶ 0 => "u=0, i" ] "accept-encoding" => array:1 [▶ 0 => "gzip, deflate, br, zstd" ] "sec-fetch-dest" => array:1 [▶ 0 => "document" ] "sec-fetch-user" => array:1 [▶ 0 => "?1" ] "sec-fetch-mode" => array:1 [▶ 0 => "navigate" ] "sec-fetch-site" => array:1 [▶ 0 => "none" ] "accept" => array:1 [▶ 0 => "text/html,application/xhtml+xml,application/xml;q=0.9,image/avif,image/webp,image/apng,*/*;q=0.8,application/signed-exchange;v=b3;q=0.7" ] "user-agent" => array:1 [▶ 0 => "Mozilla/5.0 AppleWebKit/537.36 (KHTML, like Gecko; compatible; ClaudeBot/1.0; +claudebot@anthropic.com)" ] "upgrade-insecure-requests" => array:1 [▶ 0 => "1" ] "sec-ch-ua-platform" => array:1 [▶ 0 => ""Windows"" ] "sec-ch-ua-mobile" => array:1 [▶ 0 => "?0" ] "sec-ch-ua" => array:1 [▶ 0 => ""HeadlessChrome";v="129", "Not=A?Brand";v="8", "Chromium";v="129"" ] "cache-control" => array:1 [▶ 0 => "no-cache" ] "pragma" => array:1 [▶ 0 => "no-cache" ] ]
[]
0 of 0array:5 [▼ "content-type" => array:1 [▶ 0 => "text/html; charset=UTF-8" ] "cache-control" => array:1 [▶ 0 => "no-cache, private" ] "date" => array:1 [▶ 0 => "Thu, 16 Jan 2025 01:05:28 GMT" ] "set-cookie" => array:2 [▶ 0 => "XSRF-TOKEN=eyJpdiI6IndhcTUyQ0RsUEtsSUxVWm8vQk5VUVE9PSIsInZhbHVlIjoiRnBDMDE1VzZXZFhqbjdBYTdRSHZuRW4xVER5MFgzRTMwK3c2MXdSMWF2eURjdDM0eVcxN0EzZnFuZ3lBVkZkcWRaQjd5Ny9BeTZHSlZiT3A2M1JxQTBuTWEzN2Q5N0duRUgxSzVYQ0NhbzFOOXpaUnlzRmticGh4eTJLRmU2RUIiLCJtYWMiOiJkYTgyZTZhZWVmYjc1NGY5MDRjOGMwMzcxYTAyOWUwYzJlOGNkM2JmNzc1ZjliNmQyMWQyODU3NTk2MjZmMTYxIiwidGFnIjoiIn0%3D; expires=Sat, 18 Jan 2025 13:05:28 GMT; Max-Age=216000; path=/; secure; samesite=strict ◀XSRF-TOKEN=eyJpdiI6IndhcTUyQ0RsUEtsSUxVWm8vQk5VUVE9PSIsInZhbHVlIjoiRnBDMDE1VzZXZFhqbjdBYTdRSHZuRW4xVER5MFgzRTMwK3c2MXdSMWF2eURjdDM0eVcxN0EzZnFuZ3lBVkZkcWRaQjd5N ▶" 1 => "eurekaselectnew_session=eyJpdiI6ImRXSXAxOGFMVGtmSkwvMXoyalpaUUE9PSIsInZhbHVlIjoiaFFDSXBMYjNRVVFzdWJ2N1ZTbGlDZkVlYkFDb21hNFV0STBDSG1vUDJ6VENxcHFBdHNmaXBoa09yWGpOR0F5MXNkTGR0dGJsYkNNd2VJUzNpTXFZdVVqNTZydGZxYktCS0RSYk85TVdYWWpaVVJmM3hHa1JIREJnQ3JUc3kvV0kiLCJtYWMiOiIzMmE0M2E5NGFhZGZmYWM4YjRlZGFkZjI0ZTdhOWVmODg4ZGNiMzE0OTNmZDRmMGI3MGFhZmIyOTVhMmQ1MGZlIiwidGFnIjoiIn0%3D; path=/; secure; httponly; samesite=strict ◀eurekaselectnew_session=eyJpdiI6ImRXSXAxOGFMVGtmSkwvMXoyalpaUUE9PSIsInZhbHVlIjoiaFFDSXBMYjNRVVFzdWJ2N1ZTbGlDZkVlYkFDb21hNFV0STBDSG1vUDJ6VENxcHFBdHNmaXBoa09yWGpO ▶" ] "Set-Cookie" => array:2 [▶ 0 => "XSRF-TOKEN=eyJpdiI6IndhcTUyQ0RsUEtsSUxVWm8vQk5VUVE9PSIsInZhbHVlIjoiRnBDMDE1VzZXZFhqbjdBYTdRSHZuRW4xVER5MFgzRTMwK3c2MXdSMWF2eURjdDM0eVcxN0EzZnFuZ3lBVkZkcWRaQjd5Ny9BeTZHSlZiT3A2M1JxQTBuTWEzN2Q5N0duRUgxSzVYQ0NhbzFOOXpaUnlzRmticGh4eTJLRmU2RUIiLCJtYWMiOiJkYTgyZTZhZWVmYjc1NGY5MDRjOGMwMzcxYTAyOWUwYzJlOGNkM2JmNzc1ZjliNmQyMWQyODU3NTk2MjZmMTYxIiwidGFnIjoiIn0%3D; expires=Sat, 18-Jan-2025 13:05:28 GMT; path=/; secure ◀XSRF-TOKEN=eyJpdiI6IndhcTUyQ0RsUEtsSUxVWm8vQk5VUVE9PSIsInZhbHVlIjoiRnBDMDE1VzZXZFhqbjdBYTdRSHZuRW4xVER5MFgzRTMwK3c2MXdSMWF2eURjdDM0eVcxN0EzZnFuZ3lBVkZkcWRaQjd5N ▶" 1 => "eurekaselectnew_session=eyJpdiI6ImRXSXAxOGFMVGtmSkwvMXoyalpaUUE9PSIsInZhbHVlIjoiaFFDSXBMYjNRVVFzdWJ2N1ZTbGlDZkVlYkFDb21hNFV0STBDSG1vUDJ6VENxcHFBdHNmaXBoa09yWGpOR0F5MXNkTGR0dGJsYkNNd2VJUzNpTXFZdVVqNTZydGZxYktCS0RSYk85TVdYWWpaVVJmM3hHa1JIREJnQ3JUc3kvV0kiLCJtYWMiOiIzMmE0M2E5NGFhZGZmYWM4YjRlZGFkZjI0ZTdhOWVmODg4ZGNiMzE0OTNmZDRmMGI3MGFhZmIyOTVhMmQ1MGZlIiwidGFnIjoiIn0%3D; path=/; secure; httponly ◀eurekaselectnew_session=eyJpdiI6ImRXSXAxOGFMVGtmSkwvMXoyalpaUUE9PSIsInZhbHVlIjoiaFFDSXBMYjNRVVFzdWJ2N1ZTbGlDZkVlYkFDb21hNFV0STBDSG1vUDJ6VENxcHFBdHNmaXBoa09yWGpO ▶" ] ]
0 of 0array:5 [▼ "_token" => "VfS1czBHl4eDVM07H7CWc2qbg0Zw63U8qo5cp0EU" "uc_cart_id" => "9219fa122ff5945da18148fa6b2ac3b5" "_previous" => array:1 [▶ "url" => "https://beta.benthamscience.com/article/46234" ] "_flash" => array:2 [▶ "old" => [] "new" => [] ] "PHPDEBUGBAR_STACK_DATA" => [] ]