Abstract

In the present review we integrated findings from microarray analyses of anticonvulsant treatment, discussing the replicability of the findings and their corroboration with data obtained from patients and with information from other fields of study. We further relate to the duality of several antiepileptic drugs exhibiting both anticonvulsant and moodstabilizing effects in the treatment of epilepsy and bipolar disorder, respectively.

Keywords: Epilepsy, anticonvulsants, microarrays, mood-stabilizers, Epileptic Tissue, Cytoprotection, gene expression, multiple sclerosis, inhibitory synapses, mood-stabilizing drugs, glutamate-induced apoptotic cell death, Antidepressants, ectopic granule cells, mood disorders, GABAergic dysfunction