Aqueous Microwave-Assisted Solid-Phase Peptide Synthesis Using Fmoc Strategy: In-Water Synthesis of

Keiko      Hojo; Hideki      Ichikawa; Asaki      Hara; Mare      Onishi; Koichi      Kawasaki; Yoshinobu      Fukumori

Protein & Peptide Letters

Author(s): Keiko Hojo, Hideki Ichikawa, Asaki Hara, Mare Onishi, Koichi Kawasaki and Yoshinobu Fukumori

DOI: 10.2174/092986612803217114

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Aqueous Microwave-Assisted Solid-Phase Peptide Synthesis Using Fmoc Strategy: In-Water Synthesis of "Difficult Sequences"

Page: [1231 - 1236] Pages: 6

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Abstract

A microwave assisted peptide synthesis in water using nanosized Fmoc-amino acids was developed. 5, 7, and 10 mer peptides (Leu-enkephalinamide, dermorphinamide, and a typical difficult sequence, ACP (65-74) peptide) were successfully synthesized in water according to Fmoc chemistry using water-dispersible nanoparticles with microwave irradiation.

Keywords: Solid-phase synthesis, Fmoc-amino acid, synthesis in water, difficult sequence, nanoparticles, microwave-assisted synthesis

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