Generic placeholder image

Letters in Organic Chemistry

Author(s): Chengjun Jiang and Huabin Hong

DOI: 10.2174/157017812802139654

DownloadDownload PDF Flyer Cite As
A New Practical Synthesis of Ethyl (R)-(-)-4-Cyano-3-hydroxybutyrate From (S)-3-chloro-1,2-propanediol

Page: [520 - 521] Pages: 2

  • * (Excluding Mailing and Handling)

Explore Articles
About Journal
For Authors
For Editors
For Reviewers

Abstract

A practical chemical synthesis of ethyl (R)-(-)-4-Cyano-3-hydroxybutyrate((R)-CNHB) has been accomplished from (S)-3-chloro-1,2-propanediol, which is a main by-product originating from (S,S)-Salen Co(III) catalyzed by hydrolytic kinetic resolution (HKR) of epichlorohydrin. The new synthetic approach demonstrated an efficient utilization of organic by-product for the asymmetric synthesis of the intermediate of atorvastatin.

Keywords: Atorvastatin, epichlorohydrin, by-product, (R)-(-)-4-Cyano-3-hydroxybutyrate, kinase, sterols, cholesterol, 2-propanediol, cyanide, thionyl