Author(s): Gayatri C. Patel, Khusman V. Asodaria, Hetal P. Patel and Dinesh R. Shah
Page: [395 - 404] Pages: 10
* (Excluding Mailing and Handling)
The present study was carried out with a view to enhance dissolution rate of poorly water-soluble drug glipizide (GZ) (BCS class II) using polyethylene glycol (PEG) 6000, PEG 8000 and poloxamer (PXM) 188 as carriers. Solid dispersions (SDs) were prepared by melting method using different ratios of glipizide to carriers. Phase solubility study was conducted to evaluate the effect of carrier on aqueous solubility of glipizide. SD was optimized by drug content estimation and in vitro dissolution study and optimised SD was subjected to bulk characterization, Scanning electron microscopy (SEM), Fourier transformation infrared spectroscopy (FTIR), Differential scanning calorimetry (DSC) and X-ray diffraction study (XRD). Preclinical study was performed in mice to study the decrease in blood glucose level from prepared SD compared with pure drug. Due to high solubility and drug release, PXM 188 in weight ratio of 1:2 was optimized. Decrease in blood glucose level in mice from SD was significantly higher (p < 0.05) compared to pure glipizide. Thus, solid dispersion technique can be successfully used for the improvement of the dissolution profile of GZ.
Keywords: Solid dispersion, Dissolution profile, Preclinical study
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select * from `article` where `first_page` < '395' and is_uploaded = 1 and issue_id = 4590 order by cast(first_page as SIGNED) desc limit 1| Bindings |
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| Backtrace |
|
select * from `article` where `last_page` > '404' and is_uploaded = 1 and issue_id = 4590 order by cast(first_page as SIGNED) asc limit 1| Bindings |
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| Backtrace |
|
select `language_id` from `multilanguage` where `short_code` = 'en'| Bindings |
|
| Backtrace |
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select `source_lang_label`, `target_lang_label` from `multilanguage_labels` where `target_lang_id` = 1| Bindings |
|
| Backtrace |
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select `id` from `multilanguage_article` where `article_id` = 43853 limit 1| Bindings |
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| Backtrace |
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select b.banner_link, b.banner_name, b.banner_script, b.banner_remarks, b.banner_file_name, b.banner_placement, bd.content_type, bd.content_id from `tbl_banner` as `b` inner join `tbl_banner_detail` as `bd` on `bd`.`banner_id` = `b`.`banner_id` inner join `users` as `u` on `u`.`id` = `b`.`updated_by` inner join `journal` as `j` on `j`.`journal_id` = `bd`.`content_id` where `b`.`banner_journal` = 1 and `bd`.`content_type` = 'J' and `bd`.`content_id` = 18 and `b`.`banner_from_date` <= 1744718538 and `b`.`banner_to_date` >= 1744718538 and `b`.`banner_status` = 'A' order by `b`.`banner_id` desc| Bindings |
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| Backtrace |
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select count(*) as aggregate from `uc_cart_products` where cart_id='fdcdf52df1f72236e177a6a5ffd41aae'| Backtrace |
|
200
[]
[]
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