Abstract

By facile condensation of aromatic amines 4-aminobenzoic acid, 2-amino-4, 6-dimethylpyrimidine, 3-aminopyridine, 4- bromobenzenamine and 4-methylbenzenamine with glyoxal and formaldehyde, catalyzed by acid or base under one or two step reaction sequence, five novel (±) trans-4,5-dihydroxy-1,3-diarylimidazolidines (DHDAIs) were prepared and characterized by X-ray single crystal analysis, NMR, IR and elemental analysis.

Keywords: Imidazolidine, Aromatic Amine, Glyoxal, Formaldehyde, Debus-Radziszewski reaction, Heterocyle, DHDAI, Base-catalysis, 3-diarylimidazolidines, 3-aminopyridine