Abstract

Allenes have been shown to be versatile building blocks in organic synthesis. However, the diversity of the allene chemistry offers a challenging and exquisite task for organic chemists bent on building the suitable allene substrates. A good solution might be propargyl-allenyl isomerization, which means to prepare readily available propargyl substrates. This review focuses on recent progress in the in situ propargyl-allenyl isomerization in organic synthesis, published in 1990 and later.

Keywords: Propargyl-allenyl isomerization, Allene, Cyclization, Base-promotion, Propargyl Ether, coupling–isomerization–Claisen, sulfur (selenium), bis-propargylic sulfides, cycloaddition, nitrogen