Abstract

An efficient, convenient synthesis method has been introduced for the preparation of phenylalanine containing crown ether ring by nucleophilic substitution, nitrosation and reduction reaction using benzo-crown ether and dimethyl malonate as material. The structures of the product are characterized by 1HNMR, MS and element analysis.

Keywords: Benzo-crown ether, dimethyl malonate, nitrosation, reduction, α-amino acid, synthesis, rotaxanes, catenane, supramolecular, malonate