Current Medicinal Chemistry

Author(s): John B. Bremner, Joseph I. Ambrus and Siritron Samosorn

DOI: 10.2174/092986707780831168

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Dual Action-Based Approaches to Antibacterial Agents

Page: [1459 - 1477] Pages: 19

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Abstract

This review collates and analyses recent work done on dual action approaches to tackling the mounting health problem of resistance by human pathogenic bacteria to antibacterial agents. In particular the areas reviewed include the use of two drugs in combination, dual action prodrugs, and dual action drugs (or hybrid drugs)

Keywords: Dual action antibacterials, bacterial resistance, dual action drugs, dual action prodrugs