Abstract

Background: Nuclear factor–kappa B (NF-kB) plays a pivotal role in vascular remodeling after percutaneous coronary intervention (PCI) with a stent implantation.

Methods and Results: This is the first clinical report to demonstrate the effect of NF-kB decoy oligodeoxynucleotide (ODN) on the prevention of restenosis after an eight-year observation period. We revealed that decoy ODN treatment suppressed neointimal formation in comparison to that without ODN transfected stent lesion in the same artery.

Conclusion: We showed the long-term usefulness of NF-kB decoy ODN transfer after PCI.

Keywords: CT, coronary intervention, gene therapy, nuclear factor–kappa B, oligodeoxynucleotide, restenosis, stents