Abstract

With the development of biomedical techniques, a new generation of gene delivery systems were investigated, characterized and developed. Many of them were also filed as patents. Such advanced gene delivery techniques have greatly improved gene therapy from in vitro, in vivo to clinics. In this review, three most significant gene delivery systems (physical transfection techniques, virus based delivery vectors and chemically engineered delivery systems) will be studied and their advantages, limitations, patents and applications will be discussed.

Keywords: Gene delivery, Nanotechnology, Patents