Generic placeholder image

Anti-Infective Agents

Author(s): Noopur Srivastava, K. S. Anil Kumar, Sudhir Sinha, Ranjana Srivastava and D. K. Dikshit

DOI: 10.2174/2211362611201010006

DownloadDownload PDF Flyer Cite As
Synthesis and Anti-tubercular Activities of Benzo[4,5]furo[2,3-c] Chromen -6-one Derivatives

Page: [6 - 14] Pages: 9

  • * (Excluding Mailing and Handling)

Explore Articles
About Journal
For Authors
For Editors
For Reviewers

Abstract

Synthesis and in vitro anti-tubercular activity against Mycobacterium tuberculosis H37Ra and H37Rv of a number of 3-hydroxy[2,3-c][1]benzopyran-6(H)-ones 1a-f and 3-Benzyl-8-hydroxy-1,2,3,4-tetrahydro-chromeno[3,4- c]pyridin-5-ones 8a-c has been reported. Few of the compounds exhibited anti–tubercular activity with MIC as low as 3.12 μg/ml in virulent and avirulent strains.

Keywords: BACTEC, Coumarin, MDR tuberculosis, pechman condensation, triarylmethanes, tuberculosis, BCG, Benzofurans, ANTI-TUBERCULAR ACTIVITY, DMAP