Synthesis, Photophysical and Photobiological Study of Synergic Photosensitizer:Zinc-Phthalocyanine with Ca2+ Chelating Agent

Claure   N.   Lunardi; Jeane   C.   G. Rotta; Antonio   C.   Tedesco

Current Organic Chemistry

Author(s): Claure N. Lunardi, Jeane C. G. Rotta and Antonio C. Tedesco

DOI: 10.2174/138527207780598792

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Synthesis, Photophysical and Photobiological Study of Synergic Photosensitizer:Zinc-Phthalocyanine with Ca2+ Chelating Agent

Page: [647 - 654] Pages: 8

* (Excluding Mailing and Handling)

Abstract

A novel phthalocyanine derivative containing a Ca2+ chelating agent with structure similar to EDTA has been synthesized in 3 steps. The addition of a chelating agent to the phthalocyanine macrocycle make it a synergic compound useful for PDT.

Keywords: Photoinactivation, Calcium affinity, ZnPcChel, fluorescence emission, MTT Assay

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