Abstract

A framework was developed to provide an integrated view of mycobacterial growth and its regulation. The topics reviewed include the properties of cell cultures and their relation to properties of individual cells, cell sizes and macromolecular compositions, uptake of nutrients through the cell envelope, protein biosynthesis, core metabolic pathways, generation of an electrochemical gradient of protons, ATP synthesis and the control of energy generation.

Keywords: Serine/Threonine Protein Kinases, Mycobacterium tuberculosis, NADH oxidation, ATP binding cassette, Porins, ATP synthesis