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Mini-Reviews in Organic Chemistry

Author(s): Inacio Luduvico, Mireille L. Hyaric, Mauro V. De Almeida and Adilson D. Da Silva

DOI: 10.2174/157019306775474194

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Synthetic Methodologies for the Preparation of Epothilones and Analogs

Page: [49 - 75] Pages: 27

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Abstract

Epothilones are natural products present in the myxobacterium Sorangium cellulossum strain 90. Due to their antitumoral activity, they are good candidates for the treatment of various forms of cancer, and epothilones B and D and some synthetic analogs are actually under advanced clinical trials. This review describes the synthesis of epothilones A and B and some of their analogs.

Keywords: Epothilone, antitumor compounds, total synthesis