Abstract

Calcium-based inorganic biodegradable nanomaterials (CIBNs) including calcium phosphate, hydroxyapatite (HA), calcium silicate, calcium carbonate, and calcium sulfate, are important materials and have been widely used in biomedical field. Although CIBNs have been intensively studied, there are only a few synthesis methods that showed promising characteristics for practical applications. Here, we intend to review recent progress in the synthesis of the CIBNs including both patents and papers. In addition, the mechanisms of CIBNs are introduced. Finally, the current and future developments are put forward. In summary, we briefly review the patents and the patent-interrelated papers concerning the fabrication, mechanism, and future development of CIBNs in this mini-review. The paper provides an overview about the potential application of nanotechnology in biomedical field.

Keywords: Fabrication, Calcium-Based, Biodegradable Nanomaterials, patent-interrelated, nanotechnology, biomedical field, Calcium phosphate, hydroxyapatite, calcium silicate, calcium sulfate, biodegradable, biomedical, dental implants, gas sensors, catalysts or catalysts supports, osteoconductivity, biocompatibility, bioactivity, biodegradablity, metabolic process, nanostructured, simulated body fluid (SBF), nanocrystalline silicon-substituted, nanocomposite fibers, microemulsion, sol-gel, biomimetic synthesis, mechano-chemical process, dual nozzle spray, degradability, flower-like porous, microfluidic techniques, anti-tumor activity, apoptosis-induction, apoptotic signaling, Pickering-type, solvent-casting method, drug-loading capacity, biocompatible, antibiotic-carrier material, microwave-assisted, electrospinning-hydrothermal methods, phagocytosis, protuberances, dental filling materials, radiation therapy, nanoparticles, carcinosarcoma