Current Drug Discovery Technologies

Author(s): Maria Espinosa Bosch, Antonin Jesus Ruiz Sanchez, Fuensanta Sanchez Rojas and Catalina Bosch Ojeda

DOI: 10.2174/157016309789054942

Applications of Supercritical Fluid Chromatography-Tandem Mass Spectrometry in Pharmaceuticals

Page: [214 - 229] Pages: 16

  • * (Excluding Mailing and Handling)

Abstract

Supercritical fluid chromatography (SFC) is a fully mature technique and can readily be coupled to mass spectrometers relatively easily. In the last years, supercritical fluid chromatography coupled with mass spectrometry (SFCMS) has had a great advance in productivity, due to increase in reliability and robustness of both SFC and MS systems, the need to push drug discovery faster, and as a potential solution to old problems unsolved and new problems yet to be encountered. This article will illustrate the role of SFC-MS analysis in drug discovery process.