Current Chemical Biology

Author(s): Adukamparai R.S. Babu, Raghavachary Raghunathan, Narayanasamy Mathivanan, Gurusamy Omprabhac, Devadasan Velmurugan and Rangasamy Raghu

DOI: 10.2174/2212796810802030312

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Synthesis, Characterisation, Anti-Microbial Activity and Docking Studies of Novel Dispiro- Oxindolopyrrolidines

Page: [312 - 320] Pages: 9

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Abstract

A facile synthesis and characterisation of novel dispiro-oxindolopyrrolidines is delineated. The results of the anti-microbial studies of novel dispiro-oxindolopyrrolidines are correlated with the docking calculations performed on protein S12 from 30S ribosomal subunit.

Keywords: 1,3-Dipolar cycloaddition, azomethine ylide, spiro-pyrrolidines, spiro-oxindolopyrrolidine, anti-microbial activity, 30S ribosomal subunit