A facile synthesis and characterisation of novel dispiro-oxindolopyrrolidines is delineated. The results of the anti-microbial studies of novel dispiro-oxindolopyrrolidines are correlated with the docking calculations performed on protein S12 from 30S ribosomal subunit.
Keywords: 1,3-Dipolar cycloaddition, azomethine ylide, spiro-pyrrolidines, spiro-oxindolopyrrolidine, anti-microbial activity, 30S ribosomal subunit