Current Drug Targets - Inflammation & Allergy

Author(s): A. P. Watt, B. C. Schock and M. Ennis

DOI: 10.2174/1568010054526313

Neutrophils and Eosinophils: Clinical Implications of their Appearance, Presence and Disappearance in Asthma and COPD

Page: [415 - 423] Pages: 9

  • * (Excluding Mailing and Handling)

Abstract

Asthma and chronic obstructive pulmonary disease (COPD) are common chronic disorders. Traditionally, asthma has been associated with an eosinophilic inflammation and COPD with neutrophilic inflammation. In this review we will highlight the maturation, recruitment, activation, action and apoptosis of these cells. In addition we will focus on the evidence for their presence in disease and suggest potential new therapeutic interventions.

Keywords: asthma, copd, eosinophils, neutrophils