Abstract

A facile, efficient and environment-friendly protocol for the synthesis of 3-aminoimidazo[1,2-a]pyridines has been developed by one-pot condensation of 2-aminopyridine, aromatic aldehyde and alkyl or aryl isocyanide in the presence of P2O5 as catalyst under solvent-free conditions at room temperature. The present approach offers the advantages of clean reaction, simple methodology, short reaction time, high yield, easy purification, and economic availability of the catalyst.

Keywords: Imidazo[1,2-a]pyridine, P2O5, 2-Aminopyridine, Isocyanide, pyridines, pyrimidines, montmorillonite, benzaldehyde, aminopyridnes, pentoxide