Abstract

Ultrasound-promoted synthesis of β-acetamido ketones catalyzed by cobalt sulfate heptahydrate via one-pot multi-component reaction coupling of aromatic aldehyde, acetophenone and acetyl chloride in acetonitrile was carried out in excellent yields at 25-28 °C, providing an efficient synthesis of these compounds. The use of ultrasound increased the rate of reactions compared with reactions under reflux condition.

Keywords: β-Acetamido ketones, cobalt, sulfate, heptahydrate, condensation, synthesis, ultrasound irradiation, MCRs, multi-component reaction, Dakin-West reaction, aromatic aldehyde, cobalt sulfate heptahydrate