Abstract

The condensation reactions of alkyl isocyanides with 1,3-dimethylbarbituric acid and aryl carboxaldehydes to afford 6-(alkylamino)-5-(3-aryl)-1,3-dimethylfuro[2,3-d]pyrimidine-2,4(1H,3H)-dione, in excellent yields under neutral conditions, are reported.

Keywords: Aldehydes, condensation reaction, fused heterocycles, isocyanides, 1,3-dimethylbarbituric acid, 1,3-dimethylfuro[2,3-d]pyrimidine, N-methyl groups, anti-inflammatory, antiviral, anti HIV