Author(s): Seyed S. Sajadikhah, Malek T. Maghsoodlou, Nourallah Hazeri and Sayyed M. Habibi-Khorassani
Page: [743 - 748] Pages: 6
* (Excluding Mailing and Handling)
A straightforward, simple and efficient method is described for the synthesis of pyrazolo[1,2-a][1,2,4]triazole derivates via one-pot three-component reaction between isocyanides, dialkyl acetylenedicarboxylate and 4-phenyl urazole (as a NH-acid) in acetone without using any catalyst at ambient temperature. This method offers several advantages such as high yield of products, easy work-up procedure and mild reaction conditions.
Keywords: Dialkyl acetylenedicarboxylate, isocyanide, multi-component reaction, pyrazolo[1,2-a][1,2,4]triazole, urazole, anti-inflammatory, anti-microbial, anti-hypoxic, analgesic, antibacterial
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