Efficient Syntheses of exo-Granisetron Hydrochloride and other Potential Impurities Present in Granisetron Hydrochloride, an Anti-Emetic Drug

Eda      V.R. Vishnu; Suju      Joseph; Abayee      K. Srinivasana; Ramesh      S. Gania; Govindabur      R. Reddy; Patakokila      V. Rao; Vilas      H. Dahanukara; Josyula      Ramanatham; Nayakanti      Devanna

Letters in Organic Chemistry

Author(s): Eda V.R. Vishnu, Suju Joseph, Abayee K. Srinivasana, Ramesh S. Gania, Govindabur R. Reddy, Patakokila V. Rao, Vilas H. Dahanukara, Josyula Ramanatham and Nayakanti Devanna

DOI: 10.2174/157017811799304142

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Efficient Syntheses of exo-Granisetron Hydrochloride and other Potential Impurities Present in Granisetron Hydrochloride, an Anti-Emetic Drug

Page: [722 - 727] Pages: 6

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Abstract

European Pharmacopeia mentions about nine potential impurities in Granisetron hydrochloride. These impurities need to be controlled in the API as described in the Pharmacopeia. Elegant syntheses of four potential impurities in Granisetron hydrochloride are disclosed.

Keywords: Impurity-A, impurity-C, exo-Granisetron (impurity-F), impurity-I, residual solvents, hydrochloride, alkylation, chemotherapy, Harmonization, azodicarboxylate

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