Abstract

An environmentally rapid and benign protocol for the synthesis of 4-aryl-1,4-dihydropyridines compounds using VB1 as a catalyst under microwave irradiation and solvent-free conditions has been achieved. The procedure is operationally simple, giving good to high product yield.

Keywords: 4-Aryl-1, 4-dihydropyridines, VB1, antitumor, antimutagenic, geroprotective, antidiabetic agents, bioactivity, antiaggregatory, aromatic aldehydes