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Letters in Organic Chemistry

Author(s): Jorge Trilleras, Pedro De La Torre, Dency J. Pacheco, Jairo Quiroga, Manuel Nogueras and Justo Cobo

DOI: 10.2174/157017811799304296

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Solvent-Free Microwave-Assisted Synthesis of Substituted Pyridines Using NH4OAc as Nitrogen Source

Page: [652 - 655] Pages: 4

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Abstract

New 1,5-dicarbonyl compounds were prepared, as versatile precursors to pyridine derivatives, by a tandem Claisen-Schmidt condensation/ Michael addition reaction, that is condensation between 5-chloro-3-methyl-1-phenyl-1Hpyrazole- 4-carbaldehyde and acetophenones, and the formed adduct then reacts with a second molecule of acetophenone. The preparation of substituted pyridines was achieved using NH4OAc as nitrogen source under solvent-free microwave irradiation.

Keywords: Chalcone, 1,5-dicarbonyl compounds, cyclocondensation, microwave, NH4OAc, pyridines, solvent-free procedure, heterocyclic, antifungal, antibacterial