Abstract

The reaction of 1,3-dimethyl-5-bis(thioethyl)methylene barbituric acid (2) with various vic-diamines leads to the formation of the respective 1,3-diazamethylene barbiturate derivatives 3 (a-f) in high yields. Solid-state 13C-NMR, MS and IR spectral data were employed for the characterization of these compounds. Antimicrobial screening revealed that none of the newly synthesized compounds showed appreciable antibacterial activity.

Keywords: 5-bis(thioethyl)methylenebarbiturates, 1,3-diazamethylene barbiturates, 1,3-dimethylbarbituric acid, azaheterocycles, solid-state 13C-NMR, pyrimidine, trioxopyrimidine, nucleophilic, amines, alkylation