Abstract

A simple and efficient one-pot procedure for trifluoroacetylation of arylamines using trifluoroacetic acid and triphosgene is reported. A mixed trifluoroacetic anhydride generated in situ reacts with a variety of arylamines to give the corresponding trifluroacetamides in high yields.

Keywords: Trifluoroacetylation, trifluoroacetamides, trifluoroacetic acid, arylamines, triphosgene, N-trifluoroacetylimidazole, N-(trifluoroacetoxy)succinimide, benzotriazole, poly-phosphoric acid, trimethylsilylester