Abstract

An efficient method has been developed for the synthesis of 2-amino thiazole and selenazole-5-carboxylates from β-ketoesters, thiourea or seleno urea and N-bromo succinamide by using Xanthan sulfuric acid as a solid acid catalyst. The reaction work-up is very simple and the catalyst can be easily separated from the reaction mixture and reused several times in subsequent reactions.

Keywords: Bio-supported, N-bromo succinamide(NBS), recyclable, selenazoles, thiazoles, Xanthan sulfuric acid, inflammation, hypertension, bacterial, HIV infections