Abstract

Three 2-methoxy-4-substituted pyrimidine compounds were chemoselectively synthesized by diazotization, using 2,4-dichloropyrimidine as the starting material. In nonaqueous diazotization reaction system, halo-substituted 6 and 7 were efficiently prepared, and in aqueous medium, hydrolysis product 8 was afforded.

Keywords: 2-methoxy-4-substituted pyrimidine, azaheterocycles, chemoselective synthesis, diazotization, hydrolysis, antibiotics, vitamins, alkaloids, heterocyclic pyrimidines, catalysis