Generic placeholder image

Letters in Organic Chemistry

Author(s): Haiwei Ye, Yemin Zheng, Chuanming Yu and Weihui Zhong

DOI: 10.2174/157017811796504927

DownloadDownload PDF Flyer Cite As
Enantioselective Michael Addition of Malonates to Aromatic α,β-Unsaturated Aldehydes Organocatalyzed by (S)-2-[bis(3,4,5-Trifluorophenyl) trimethylsilanyloxymethyl]pyrrolidine

Page: [520 - 525] Pages: 6

  • * (Excluding Mailing and Handling)

Explore Articles
About Journal
For Authors
For Editors
For Reviewers

Abstract

The Michael addition of malonates to aromatic α,β-unsaturated aldehydes was efficiently organocatalyzed by (S)-2-[bis(3,4,5-trifluorophenyl)trimethylsilanyoxymethyl]pyrrolidine, derived from L-proline to afford the corresponding adducts in good yields with good to excellent enantioselectivities.

Keywords: (S)-2-[bis(3,4,5-trifluorophenyl)trimethylsilanyloxymethyl]pyrrolidin, enantioselectivity, Michael addition, organocatalysis, α,β-unsaturated, aldehydes, malonates, L-proline, pyrrolidinemethanol