Abstract

A novel, solvent free and efficient one pot synthesis of 1, 4-dihydropyridine derivatives was achieved in good yields via three component reaction of aldehydes, ethyl acetoacetate and ammonium acetate using inexpensive β- cyclodextrin as a supramolecular catalyst. The catalyst can be recovered and reused without loss of activity.

Keywords: 1, 4-dihydropyridine (1, 4-DHPs), hantzsch reaction, one pot condensation, β- Cyclodextrin (β-CD), aldehydes, acetoacetate, ethyl, ammonium, anti-inflammatory agent, bronchodilator