Abstract

A novel protocol for the synthesis of Ibutilide Fumarate (raceme) was achieved from 2-pyrrolidinone with an overall yield of 15%. The core structure was constructed in one step based on Friedel-Crafts acylation with an acyl chloride containing an amino hydrochloride.

Keywords: Friedel-Crafts acylation, Ibutilide, synthesis, fumarate, antiarrhythmic, pyrrolidinone, repolarization, extravascular distribution, cardioversion, methylsulfonyl