Abstract

Phosphonation of β-nitro-alkene with triethyl phosphite was achieved under microwave irradiation using CH2Cl2 as the solvent in the absence of catalyst with moderate to high yields (up to 90%). This method of formation of carbonphosphor bonds is simple, mild, convenient and effective. Synchronously, a number of vinylphosphonates derivatives were synthesized and evaluated biologically preliminary.

Keywords: Vinylphosphonate, phosphonation, triethyl phosphite, B-nitro-alkene, microwave irradiation, carbonphosphor, enantioselective, Phosphorus-alkene bonds, organophosphorus, Horner-Wadsworth-Emmons reaction