Abstract

An ultrasonic-assisted, one-pot, efficient, convenient procedure for the synthesis of (3-phenylisoxazol-5- yl)methanol derivatives has been developed. (3-Phenylisoxazol-5-yl)-methanol derivatives with biological and pharmaceutical property have been synthesized in moderate to excellent yields. The synthetic methods possess the advantages of high yield, facile operation process and shorter reaction time, and so on.

Keywords: Ultrasound, aldoximes, 1,3-dipolar cycloaddition, nitrile oxide, isoxazole, one-pot synthesis, pharmacophores, hydroxylamine, herbicide, phenylisoxazol