Abstract

An environmentally benign Biginelli reaction for the large-scale preparation of substituted 3,4- dihydropyrimidin-2(1H)-ones using protic acids as a catalyst has been achieved. These mechanochemical reactions proceed efficiently in the absence of organic solvent, with the assistance of infrared lamp irradiation.

Keywords: Biginelli reaction, 3,4-dihydropyrimidin-2-ones, solvent-free reaction, large-scale, mechanochemical reaction, toxicity, dicarbonyl, dihydropyrimidine, aldehyde, carboxylate