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Letters in Organic Chemistry

Author(s): Fafu Yang, Biqiong Hong, Hongyu Guo, Zhisheng Huang and Xiaoyi Zhang

DOI: 10.2174/157017811795685009

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Synthesis of Novel Chiral Calix[4]crown: Lariat Calix[4]-1,3-aza-crown with Chiral Amino Acid Group as Branched Chain

Page: [358 - 360] Pages: 3

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Abstract

The novel lariat calix[4]-1,3-aza-crowns with chiral amino acids groups as branched chain (5a) and (5b) were synthesized via “1+1” addition of calix[4]-1,3-substituted benzaldehyde derivative (4) and amino acids hydrazide derivatives (3a) and (3b) in yields of 70% and 75%, respectively.

Keywords: Calix[4]crown, chiral, amino acid, aza, lariat, calixarene, alkaloids, peptides, alcohol, amino