Abstract

Myocardial tissue engineering involves the design of biomaterial scaffolds, aiming at regenerating necrotic myocardium after myocardial infarction. Biomaterials provide mechanical support to the infarct area and they can be used as vehicles for sustained and controlled local administration of cells and growth factors. Although promising results have been reported in experimental studies, many issues need to be addressed before human use.

Keywords: Biomaterial scaffold, cardiac repair, heart failure, myocardial infarction, ventricular remodeling, tissue engineering, necrotic, Hypertrophy, Infarct Healing, Gelatin, Nano-Clays, Alginate