Efficient Synthesis of 5-Arylmethyl-5-phenylimidazolidine-2,4-dione (or 5-Arylmethyl-5-phenyl-2-thioxoimidazolidin-4-one) from Chalcone Oxides Under Ultrasound Irradiation

Ji-Tai      Li; Xiao-Ya      Xu; Ying      Yin

Letters in Organic Chemistry

Author(s): Ji-Tai Li, Xiao-Ya Xu and Ying Yin

DOI: 10.2174/157017811795038403

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Efficient Synthesis of 5-Arylmethyl-5-phenylimidazolidine-2,4-dione (or 5-Arylmethyl-5-phenyl-2-thioxoimidazolidin-4-one) from Chalcone Oxides Under Ultrasound Irradiation

Page: [198 - 201] Pages: 4

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Abstract

Synthesis of 5-arylmethyl-5-phenylimidazolidine-2,4-dione (or 5-arylmethyl-5-phenyl-2-thioxoimidazolidin-4- one) via the reaction of 3-aryl-2,3-epoxyl-1-phenyl-1-propanone and urea (or thiourea) was carried out in 57-98% yields at 50 °C in EtOH in the presence of KOH under ultrasound irradiation. The procedure has the advantages of mild conditions, short reaction time and high yield.

Keywords: Substituted hydantoin, synthesis, chalcone oxide, ultrasound irradiation, seizures, convulsions, epoxyl, methoxyphenyl, propanone, imidazolidine

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