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Letters in Organic Chemistry

Author(s): Zhiyi Yao, Xin Zeng, Wei Yi and Sheng Jiang

DOI: 10.2174/157017811794557868

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Stereoselective Synthesis of (S,E)-2-(trimethylsilyl)ethyl 3-hydroxy-7- (tritylthio)hept-4-enoate

Page: [66 - 69] Pages: 4

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Abstract

(S,E)-2-(trimethylsilyl)ethyl 3-hydroxy-7-(tritylthio)hept-4-enoate was synthesized from commercially available L-malic acid by the Julia-Kocienski olefination coupling method. This method provides a concise synthetic strategy for (S,E) -3-hydroxy-7-mercaptohept-4-enoic acid.

Keywords: (S,E)-3-hydroxy-7-mercaptohept-4-enoic acid, Julia-Kocienski olefination coupling, L-malic acid