Abstract

Enaminones were efficiently prepared via modification for Gupton method, which depends on carrying out the latter procedure in one step reaction, avoiding the isolation of [3-(dimethylamino)-2-azaprop-2-en-1- ylidene]dimethylammonium chloride (Golds reagent) (5) which is prepared in situ from cyanuric chloride (4) then it reacts successfully with ketone 1a-j to produce the enaminones 3a-j in suitable yields. The modified method overcomes the drawbacks of the known methods for preparation of enaminones.

Keywords: Enaminone, cyanuric chloride, gold's reagent, DMF-DMA, Ketone