Generic placeholder image

Letters in Organic Chemistry

Author(s): Ming Lei, Wang-Ze Song, Zu-Jin Zhan, Sun-Liang Cui and Fang-Rui Zhong

DOI: 10.2174/157017811795038430

DownloadDownload PDF Flyer Cite As
Multicomponent Reactions Stereo- and Regioselective Three-Component Reaction in Water: Synthesis of Triazole Substituted β-Lactams Via Click Chemistry

Page: [163 - 169] Pages: 7

  • * (Excluding Mailing and Handling)

Explore Articles
About Journal
For Authors
For Editors
For Reviewers

Abstract

Three-component reaction in water was used to prepare a series of triazole substituted trans-β-lactams from the corresponding trans-4-acetoxy-lactam, sodium azide, and alkynes via a Cu(I)-catalyzed click chemistry with base free. This highly stereo- and regioselective procedure is simple, clean and efficient.

Keywords: Three-component reaction, β-lactam, 3R,4R-4-acetoxy-3-[(R)-1-((tert-butyldimethyl-silyl)oxy)-ethyl]-2-azetidinone, click reaction, triazole, stereo- and regioselective reaction, monobactams, carbacephems, carbapenems, sulfinylazetidin