Abstract

Currently, polycationic nanoparticles (polycation) as nonviral vectors are promising to overcome the defects of traditional viral vectors. This review focuses on the recent progress and challenges to improve the transfection efficacy and circulation time of polyplexes (complexes between polycation and pDNA or oligonucleotides such as siRNA ) in vivo.

Keywords: Gene therapy, polycation, nanoparticles, non-viral vectors, transfection efficiency, PEGylation, gene delivery, circulation time